NCLEX Oncology Practice Exam

NCLEX Oncology Practice Exam | 2025/2026 Latest Edition Real Exam-Based Questions and Verified Answers | 100% Accuracy | Cancer Nursing Care & Treatment Modalities | Graded A+ Introduction This resource includes 75 multiple-choice questions and verified correct answers focused on oncology nursing, updated for the 2025/2026 NCLEX-RN/PN cycle. Topics covered include cancer pathophysiology, chemotherapy, radiation therapy, palliative care, nursing interventions, and patient education. All content is aligned with the latest NCLEX test plan and clinical guidelines.Answer Format All correct answers are clearly marked in bold and green for efficient review and clinical mastery.

Questions (1–75)

• A client with breast cancer is scheduled for a lumpectomy. Which

statement by the client indicates a need for further teaching?

• “I will have radiation therapy after the surgery.”
• “The surgery will remove the tumor and some surrounding tissue.”
• “This procedure will remove my entire breast.”
• “I may need chemotherapy depending on the pathology results.”

c) This procedure will remove my entire breast.

Rationale: A lumpectomy removes the tumor and a margin of surrounding tissue, not the entire breast, which describes a mastectomy.

• A nurse is caring for a client receiving chemotherapy. Which

laboratory value should the nurse monitor for potential neutropenia?

a) Hemoglobin

b) Platelet count

c) Absolute neutrophil count (ANC) 1 / 3

d) Red blood cell count

c) Absolute neutrophil count (ANC)

Rationale: ANC is used to assess for neutropenia, a common side effect of chemotherapy that increases infection risk.

• A client with lung cancer reports severe dyspnea. What is the nurse’s

priority action?

a) Administer a bronchodilator

b) Assess oxygen saturation

c) Encourage deep breathing exercises

d) Provide a high-protein diet

b) Assess oxygen saturation

Rationale: Assessing oxygen saturation is the priority to determine the severity of dyspnea and guide interventions.

• A client receiving radiation therapy for cervical cancer reports skin

redness at the treatment site. What should the nurse recommend?

a) Apply a heating pad to the area

b) Use a gentle, fragrance-free moisturizer

c) Scrub the area with a washcloth

d) Expose the area to sunlight

b) Use a gentle, fragrance-free moisturizer

Rationale: Gentle, fragrance-free moisturizers soothe radiation-induced skin irritation without causing further damage.

• A client with leukemia is prescribed vincristine. Which side effect

should the nurse monitor for?

a) Peripheral neuropathy

b) Hyperglycemia

c) Hypertension

d) Weight gain

a) Peripheral neuropathy

Rationale: Vincristine, a vinca alkaloid, commonly causes peripheral neuropathy, such as numbness or tingling. 2 / 3

• A client with colorectal cancer asks about the purpose of a

colonoscopy. What is the nurse’s best response?

• “It removes cancerous tissue from the colon.”
• “It visualizes the colon to detect abnormalities.”
• “It delivers chemotherapy directly to the colon.”
• “It measures the tumor’s response to radiation.”

b) It visualizes the colon to detect abnormalities.

Rationale: A colonoscopy is a diagnostic procedure to visualize the colon and detect abnormalities like tumors or polyps.

• A client with pancreatic cancer reports severe abdominal pain. Which

intervention should the nurse prioritize?

a) Administer a prescribed opioid analgesic

b) Encourage a high-fiber diet

c) Apply a cold pack to the abdomen

d) Restrict fluid intake

a) Administer a prescribed opioid analgesic

Rationale: Severe pain in pancreatic cancer often requires opioid analgesics for effective management.

• A client receiving chemotherapy reports nausea and vomiting. Which

medication should the nurse anticipate administering?

a) Ondansetron

b) Furosemide

c) Metoprolol

d) Insulin

a) Ondansetron

Rationale: Ondansetron, a serotonin receptor antagonist, is commonly used to manage chemotherapy-induced nausea and vomiting.

• A client with prostate cancer is prescribed leuprolide. What is the

primary purpose of this medication?

a) Reduce tumor size

b) Suppress testosterone production

c) Prevent infection

• / 3