NR 565 MIDTERM ACTUAL EXAM TEST

NR 565 MIDTERM ACTUAL EXAM TEST/

- MIDTERM TEST

GRADED A+

What are the key responsibilities of prescribing? Correct Answer A sound understanding of drugs and the conditions that they are used to manage Be deliberate in decision-making process Do not prescribe for family or friends Document thorough history and physical for the records, including education provided on drug Have a documented plan for monitoring and titration

What should be used in making prescribing decisions? Correct Answer Cost, follow current guidelines, availability, interactions, side effects, allergies, hepatic/renal function, need for monitoring, special populations

PK and PD changes in older adults and how that affects how you prescribe? Correct Answer Very high risk of adverse drug reactions and drug-drug interactions D/t altered PK, multiple and severe illnesses, polypharmacy, poor adherence 1 / 3

Beer's Criteria Correct Answer List of potentially inappropriate medications to use in the older populations Updated annually Prescribers ultimately decide whether to prescribe or not

Impacts/outcomes of polypharmacy? Correct Answer Increased ADRs and drug-drug interactions

What are CYP450? Correct Answer Enzymes responsible for drug metabolism (biotransformation)-oxidization, reduction, hydrolyzed to promote renal dug excretion Hepatic enzyme system, composed of 12 enzyme families

What do CYP450 enzymes do? Correct Answer Promote drug excretion by making them more "excretable"--hydrophilic/water soluble and charged (ion) Inactivate drugs, increase therapeutic action through metabolism, activate a prodrug, decrease drug toxicity

CYP450 inhibitor examples? Correct Answer VISA credit card debt inhibits spending on designers like CK to look GQ Valproate Isoniazid 2 / 3

Sulfonamides Amiodarone Chloramphenicol Ketoconzaole Grapefruit juice Quinidine

What do CYP450 inhibitors do? Correct Answer Decrease the rate of metabolism Act on liver through process of inhibition Slows rate of metabolism, increases active drug accumulation which can lead to adverse reactions and drug toxicity

What do CYP450 inhibitors do if not used correctly? Correct Answer Can lead to adverse effects and drug toxicity

What happens when someone has a poor metabolism phenotype? Correct Answer Associated with accumulation of drugs in the body and they may experience drug toxicity

What does the US FDA regulate when it comes to medications?Correct Answer Regulates safety and effectiveness of drugs sold in US

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