NR546 Actual Final Exam Prediction

 NR546 Actual Final Exam Prediction questions (All correct answers, Already graded A) Prefrontal aCortex aSymptoms aof aMDD a- aCorrect a aAnswer a- aConcentration Mental aFatigue Mood PFC a& aAmygdala aSymptoms aof aMDD a- aCorrect a aAnswer a- aGuilt Suicidality Worthlessness Striatum aSymptoms aof aMDD a- aCorrect a aAnswer a- aPhysical afatigue Nucleus aAccumbens aSymptoms aof aMDD a- aCorrect a aAnswer a- aPleasure ainterests Hypothalamus aSymptoms aof aMDD a- aCorrect a aAnswer a- aSleep Appetite Thalamus a& aHypothalamus aSymptoms aof aMania a- aCorrect a aAnswer a- aDecreased asleep/arousal Striatum aSymptoms aof aMania a- aCorrect a aAnswer a- aMotor/agitation Prefrontal acortex a(PFC) aSymptoms aof aMania a- aCorrect a aAnswer a- aRisk-taking Talkative/pressured aspeech Nucleus aAccumbens a& aPFC aSymptoms aof aMania a- aCorrect a aAnswer a- aRacing athoughts, agrandiosity PFC a& aAmygdala aSymptoms aof aMania a- aCorrect a aAnswer a- aMood Medication aManagement a- aCorrect a aAnswer a- aSSRI-Selective aSerotonin aReuptake aInhibitors *Inhibit a5 aHT areuptake SNRI-Serotonin aNorepinephrine aReuptake aInhibitors a *inhibit a5-HT areuptake *inhibit aNE areuptake a(increase aenergy, afocus) *increase aDA ain aprefrontal acortex a(increase acognition) NDRI-Norepinephrine aDopamine aReuptake ainhibitors

*inhibit aDA areuptake a(increase aalertness, amotivation) *inhibit aNE areuptake a(increase aenergy) SARI-Serotonin aAntagonist aReuptake aInhibitors Selective aSerotonin aReuptake aInhibitors a(SSRIs): aMost aadverse aeffects awill asubside aafter a4-5 adays aonce athe abody aadjusts ato aincreased aserotonin alevels. a- aCorrect a aAnswer a- adiarrhea headache weight again sexual aside aeffects Serotonin aNorepinephrine aReuptake aInhibitors a(SNRIs): aMedications ashould anot abe aabruptly astopped ato aavoid adiscontinuation asymptoms. aNE aeffects aof athe amedication amay aincrease aanxiety ain asome aclients. aReport aworsening aanxiety ato athe aprovider. a- aCorrect a aAnswer a- aelevated ablood apressure anxiety insomnia constipation Norepinephrine aDopamine aReuptake aInhibitors a(NDRI): aTake amedication ain athe amorning. aStop ataking amedication aif aseizures aoccur. aStop ataking amedication aif aanxiety ais anoted. a- aCorrect a aAnswer a- aagitation headache dry amouth constipation weight aloss escitalopram a(Lexapro) aSSRI a- aCorrect a aAnswer a- ano aknown adrug ainteractions best atolerated aSSRI 27-32 ahour ahalf-life agood afor aforgetful aprone aclients least aCYP areactions Substrate afor a3A4 citalopram a(Celexa) aSSRI a- aCorrect a aAnswer a- amild aantihistamine aeffects; aHalf-Life: a23- 45 ahours Weak aInhibitor aof a2D6 fluoxetine a(Prozac) aSSRI a- aCorrect a aAnswer a- alongest ahalf-life Use acaution ain apatients awith acomorbid aanxiety adue ato arisk afor aactivation aand apanic aattacks

Half-Life: a2-3 adays aparent, a2 aweek ametabolite

Inhibits a2D6 aand a3A4 paroxetine a(Paxil) aSSRI a- aCorrect a aAnswer a- aalso atreats asocial aanxiety aand ainsomnia associated awith aweight again will aexperience awithdrawal awith amissed adose aor aabrupt astop

Half-Life: a24 ahours

Inhibits a2D6 fluvoxamine a(Luvox) aSSRI a- aCorrect a aAnswer a- atreats aanxious adepression asmokers arequire aan aincreased adose

Half-Life: a9-28 ahours

Inhibits a3A4, a2C9, a1A2 sertraline a(Zoloft) aSSRI a- aCorrect a aAnswer a- aalso atreats asocial aanxiety aand ahypersomnolence

Half-Life: a22-36 ahour aparent; a62-104 ahour ametabolite

Inhibits a2D6 aand a3A4 aweakly aat alow adoses venlafaxine a(Effexor) a- aCorrect a aAnswer a- atreats aboth adepression aand aanxiety adisorders, aensure atrial aof ahigher adose abefore aswitching ato aa adifferent amedication

Half-life: aParent adrug a3-7 ahour; ametabolite ahas a9-13 ahour

duloxetine a(Cymbalta) aSNRI a- aCorrect a aAnswer a- aeffective afor aatypical apain aat ahigher adoses; aappropriate afor aclients awho apresent awith asomatic asymptoms aof adepression; aeffective afor aatypical apain, asuch aas afibromyalgia aand adiabetic aneuropathy

Half-Life: a12 ahours

Inhibitor aof a2D6 bupropion a(Wellbutrin) a- aCorrect a aAnswer a- aNDRI amay aimprove aenergy, aalertness, aand amotivation; anot afirst-line atreatment afor aanxiety; acontraindicated ain aclients awith aa ahistory aof aseizures Avoid ain apatients awith acomorbid aanxiety

Half-Life: aParent a10-14 ahours; aMetabolite a20-27 ahours

Inhibits a2D6 Serotonin aAntagonist aand aReuptake aInhibitors a(SARIs) a- aCorrect a aAnswer a- aSARIs apotently ablock a5-HT2A aand a5HT a2C areceptors, awhich aallow amore a5-HT ato ainteract aat apostsynaptic a5-HT1A asites. aSerotonin ablockade aand areuptake ainhibition ais apresent aat ahigher adoses.Trazodone a- aCorrect a aAnswer a- aThe amost acommon aSARI, aalso ablocks ahistaminergic aand aα-adrenergic areceptors.

Half-Life: a3-6 ahours

Serotonin aAntagonist aand aReuptake aInhibitors a(SARIs) a- aCorrect a aAnswer a- aCommon aAdverse aEffects · asedation · adrowsiness · ablurred avision · aconstipation · adry amouth

Serious aAdverse aEffect priapism Serotonin anorepinephrine areceptor aagonist, aalpha2 areceptor aagonist a- aCorrect a aAnswer a- aMirtazapine Serotonin amultimodal a(SMM)/serotonin apartial aagonist areuptake ainhibitor a(SPARI) a- aCorrect a aAnswer a- aVilazodone a(Viibryd) · aInhibits aserotonin areuptake awith apartial a5HT1A aagonism Appropriate afor adepression/comorbid aanxiety, aits aaction ais asimilar ato aa acombination aof aSSRI aand abuspirone Serotonin amultimodal a(SMM) a- aCorrect a aAnswer a- aVortioxetine a(Trintellix) · aActs aas aSSRI aplus a5HT1A apartial aagonism · aImproves adepression-related acognition Tricyclic aantidepressants a(TCAs) a- aCorrect a aAnswer a- aTricyclic aantidepressants a(TCAs) apossess aboth aSRI aand aNRI aproperties, abut athey aalso ablock aother areceptors, aincluding aα1-adrenergic, ahistamine-1, aand amuscarinic acholinergic areceptors. aTCAs aare anot aused afirst-line abecause aof athe ahigh aincidence aof aadverse aeffects aand athe arisk aof apotential aoverdose aand adeath adue ato aoverdose

Tricyclic aantidepressants a(TCAs) a- aCorrect a aAnswer a- aDrugs:

· aamitriptyline a(Elavil) · adesipramine a(Norpramin) · adoxepin a(Sinequan) · aimipramine a(Tofranil) · anortriptyline a(Pamelor) Tricyclic aantidepressants a(TCAs) a- aCorrect a aAnswer a- aCommon aadverse aeffects aof aTCAs Alpha-1 aadrenergic aeffects-Orthostatic ahypotension Histamine aeffects-Sedation Histamine aeffects-Weight again Anticholinergic aeffects-Blurred avision Anticholinergic aeffects-Urinary aretention Anticholinergic aeffects-Constipation Anticholinergic aeffects-Dry amouth MAOIs a- aCorrect a aAnswer a- aLast achoice amedication aclass afor adepression adue ato athe amany apotential, aserious aside aeffects. aMAOIs ahave aspecific adietary arestrictions athat awhen aignored, amay abe avery auncomfortable aor avery aserious afor aclients.

MAOIs a- aCorrect a aAnswer a- aDrugs:

· aphenelzine a(Nardil) · aselegiline a(Emsam) a- aMAOI-B