NURS 5463 - Mod 3 - Platelet Disorders Latest

NURS 5463 - Mod 3 - Platelet Disorders Latest Update - Sources with Questions and Verified Correct Answers Golden Ticket to Guaranteed A+ Verified by Professor

ADAMTS13 in TTP - CORRECT ANSWER: Severe deficiency < 10% confirms

diagnosis Low level (10-60%) - occurs in sepsis, malignancy & those w/ TTP who receive many transfusions) Normal >60% - TTP unlikely (Test not necessarily reliable, don't wait for results to initiate treatment)

Anticoagulant proteins - CORRECT ANSWER: antithrombin and tissue factor pathway

inhibitor

Causes of Thrombocytopenia - CORRECT ANSWER: -hemodilution (occurs post op,

drop in 20-70%, usually nadir in 2-4 days) -Hypersplenism (platelets destroyed in the spleen) -HIV -Viral infections -SLE

Chronic IT Therapy - CORRECT ANSWER: Managed by hematology

Splenectomy Immune suppression with Rituximab For those who want to avoid splenectomy & Rituximab - Rominplostim & Fostamatinib

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Coagulation proteins - CORRECT ANSWER: Fibrinogen, Factor V, VII, VIII, IX, XIII, high molecular weight kininogen, prekallikrein

Conjugated Estrogen - CORRECT ANSWER: controls more chronic bleeding

IV, PO or transdermal 0.6mg/kg daily for 5 days effects seen in 1st day and peak at 5-7 days, lasts a week or more after dc

Correcting Anemia r/t Uremic Bleeding - CORRECT ANSWER: Growth factors or

transfusions if acutely bleeding Give PRBC to keep HCT at 30%

• unit PRBCs will raise H/H by 1G or 3%

Desmopressin (dDAVP) - CORRECT ANSWER: IV or SC

• Increases levels of Factor VIII and von Willebrand factor
• Improvement seen within 1 hour and lasts up to 4-8 hours
• Max effect reached in 1-2 doses
• Watch for hyponatremia and water intoxication

Drugs that Ti Thrombocytopenia - CORRECT ANSWER: Sulfonamides

Quinine (tonic water) Heparin Eptifibatide (Integrillin) Rifampin (Rifadin) Beta lactam antibiotics (PCN, Cephalosporins) Carbamazepine (Tegretol) Levofloxacin (flouroquinolones) Vancomycin Linezolid (Zyvox)

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