ONSONCC CHEMOTHERAPY

ONS/ONCC CHEMOTHERAPY

IMMUNOTHERAPY CERTIFICATE EXAM

Define mutations Correct Answer Variations in the nucleotide sequence of a gene

3 main goals of treatment: Correct Answer Cure

Control Palliation

Define neoadjuvant therapy Correct Answer Treatment is given prior to surgery to shrink the tumor

Define adjuvant therapy Correct Answer Additional cancer treatment given after the primary treatment to lower the risk that the cancer reoccur

Define conditioning/preparative therapy Correct Answer Treatments used to prepare a patient for stem cell transplantation

• types of conditioning therapies: Correct Answer Myeloablative 1 / 4

Nonmyeloablative

Define dose density Correct Answer Drug dose per unit of time

Define dose intensity Correct Answer Amount of drug delivered over time

How is relative dose intensity (RDI) calculated? Correct Answer By comparing the dose that the patient ACTUALLY received to the planned dose of the standard regimen

How do alkylating agents work? Correct Answer By causing a break in the DNA helix strand, interfering with DNA replication and causing cell death

3 subcategories of alkylating agents: Correct Answer 1. Nitrogen

mustards

• Platinum-based agents (do not possess an alkyl group but still

termed alkylating agents as they work similarly)

• Nitrosoureas

Most common subcategory of alkylating agents: Correct Answer

Nitrogen mustards

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Common alkylating agents: Correct Answer Cyclophosphamide

(Cytoxan) Ifosfamide (Ifex) Bendamustine (Treanda)

Common platinum-based agents: Correct Answer Cisplatin

(Platinol) Carboplatin (Paraplatin)

What is unique about nitrosoureas agents? Correct Answer Able to cross the blood-brain barrier; can be effective in treating some brain tumors

Common nitrosoureas agents: Correct Answer Carmustine

(BiCNU) Lomustine (CeeNu) Streptozocin (Zanosar)

Hypersensitivity can occur with late doses of: Correct Answer

Carboplatin

These agents are typically categorized as highly emetogenic:

Correct Answer 1. Alkylating agents

• Nitrosoureas 3 / 4

Pre-administration labs for alkylating agents and nitrosoureas:

Correct Answer BUN Creatinine CBC w/ diff

What is the medication Mesna used for? Correct Answer Bladder protectant with administration of cyclophosphamide or ifosfamide

Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days following treatment Correct Answer Oxaliplatin

How do antimetabolites function? Correct Answer By blocking DNA and RNA growth by interfering with enzymes needed for normal cell metabolism

Antimetabolites work in the ___ phase. Correct Answer S

What types of cells are best affected by antimetabolites? Correct Answer Cells with high division rates

Common side effects of antimetabolites: Correct Answer

Myelosuppression

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