prolonged use of NSAIDs can interfere with the protective mechanisms of the gastrointestinal mucosa, leading to the

WEEK 5 Edapt:

Pep�c Ulcer Disease Key Concepts 1 / 2

NR 507: Week 5 Edapt: Peptic Ulcer Disease PUD is commonly associated with Helicobacter pylori (H. pylori) bacterial infection. H. pylori can colonize the gastric mucosa, leading to chronic inflammation and disruption of the mucosal barrier. This can result in increased acid secretion, impaired mucus production, and the development of ulcers.Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are well-known risk factors for PUD. Regular and prolonged use of NSAIDs can interfere with the protective mechanisms of the gastrointestinal mucosa, leading to the development of ulcers.Excessive alcohol consumption is a recognized risk factor for PUD. Alcohol can irritate the gastric mucosa and increase the production of gastric acid, contributing to the development of ulcers.Advancing age is associated with an increased risk of PUD. Older individuals may experience changes in the mucosal lining of the stomach that make them more susceptible to ulcers.A family history of PUD suggests a potential genetic predisposition. Genetic factors may influence an individual's susceptibility to developing ulcers.Downloaded by Benjamin Luca ([email protected]) lOMoARcPSD|51648332

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