Review inotropic, chronotropic and dromotropic effects of

UNIT X-A

Cardiac Glycosides Drugs

By: Muhammad Aurangzeb

Lecturer-INS/KMU

By the end of this unit learners, will be able to:

•Review inotropic, chronotropic and dromotropic effects of cardiovascular drugs.•Describe the therapeutic effects and therapeutic uses of digoxin.•Discuss digitalization.•Discuss the signs and symptoms of early moderate and severe digoxin toxicity.•Describe the nursing care related to digoxin toxicity.•Discuss pharmacological management of arrhythmias.•Discuss nursing implication in relation to antiarrhythmic drugs.•Calculate the drug dosage accurately while administering oral and parenteral medication Objectives

What is a failing Heart ???Inability of the heart to pump sufficient blood to meet the metabolic demands of the body •Systolic - In IHD, Valvular incompetence, cardiomyopathy and myocarditis etc.•Diastolic - In Hypertension, aortic stenosis, congenital heart disease and hypertrophic cardiomyopathy Reduced efficiency of the heart as a pump – reduced Cardiac Output

Cardioactive glycosides Drugs having the cardiac Inotropic property – increase in force of contraction and cardiac output in a failing (hypodynamic) heart – They increase the myocardial contractility and improves cardiac output without proportionate increase in Oxygen consumption - Cardiac Tonic – Do not increase the heart rate • In contrast, Sympathomimetics or the cardiac stimulants increase Heart Rate and Oxygen consumption without increase in cardiac output

MYOCARDIAL EFFICIENCY !