UNE BIOCHEM 1005 ACTUAL FINAL EXAM

UNE BIOCHEM 1005 (ACTUAL / ) FINAL EXAM

QUESTIONS AND VERIFIED ANSWERS

If an individual with type I diabetes were to have an episode of diabetic ketoacidosis with respiratory compensation, which of the following lab values would be consistent with this presentation before any treatment?

• Increased blood pH
• Decreased blood pH
• Decreased blood glucose
• Decreased ketone synthesis - --Answers---b. Decreased

blood pH

Elevated levels of NADH produced from the oxidation of alcohol can disrupt the TCA cycle. Which of the following best describes the interaction of NADH with alpha ketoglutarate dehydrogenase?

• NADH facilitates a covalent modification
• NADH is an allosteric activator
• NADH is an inhibitor
• NADH inhibits translation of the enzyme - --Answers---c.

NADH is an inhibitor

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A 2-year old boy is found to have a pituitary tumor that increases secretion of ACTH. This will lead to an increase in the secretion of which of the following hormones?

• Insulin like growth factor 1 (IGF1)
• Somatostatin
• Thyroid hormone
• Cortisol - --Answers---d. Cortisol

Which of the following is a direct impact of growth hormone on metabolic processes?

• Decrease in skeletal muscle protein synthesis
• Increase in hepatic gluconeogenesis
• Decrease in hepatic glycogenolysis
• Increase in glucose uptake in skeletal muscle - --Answers-

--b. Increase in hepatic gluconeogenesis

A 5-year old boy is diagnosed with hyperinsulinemia (elevated levels of insulin). In this individual, which of the following would be consistent with this presentation?

• Hyperlipidemia (increased free fatty acids)
• Hypoglycemia
• Hyperglycemia 2 / 3

• Hyper ketosis (elevated ketone production) - --Answers---
• Hypoglycemia

Glucocorticoids such as cortisol stimulate the activity of two opposing pathways. Which of the two pathways are both stimulated by elevated levels of cortisol?

• Lipolysis and β-oxidation
• Glycogen synthesis and gluconeogenesis
• Protein catabolism and skeletal muscle protein synthesis
• Glycolysis and gluconeogenesis - --Answers---b. Glycogen

synthesis and gluconeogenesis

There are several key regulatory enzymes in gluconeogenesis.Which of the following answers below lists these enzymes in the correct order in which they are used for glucose production?

• Pyruvate carboxylase; phosphoenol pyruvate carboxykinase

(PEPCK); Fructose 1,6 bisphosphatase

• Pyruvate carboxylase; phosphoenol pyruvate carboxykinase

(PEPCK); phosphofructokinase 2 (PFK2)

• Pyruvate carboxylase; PEPCK; hexokinase
• Pyruvate kinase; pyruvate dehydrogenase;

phosphofructokinase 1 (PFK1) - --Answers---a. Pyruvate carboxylase; phosphoenol pyruvate carboxykinase (PEPCK); Fructose 1,6 bisphosphatase

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