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Week 1 Midterm: NR565 / NR-565
(Latest Update 2025 / 2026) Advanced Pharmacology Fundamentals | Test Module Questions & Answers | 100% Correct | Grade A - Chamberlain
Question:
What happens when someone has a poor metabolism phenotype?
Answer:
- Slowed metabolism of a prodrug into an active drug, leading to
accumulation of prodrug
- Accumulation of inactive metabolites of drugs
- A need for increased dosages of medications
- Increased elimination of an active drug
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Question:
What dos the U.S. Food and Drug Administration regulate when it comes to medications?
Answer:
Regulates what the pharmacies can sell, requires special alerts and management guidelines, for drugs that cause serious adverse effects
Ensuring pharmaceutical companies thoroughly test new products for efficacy and safety with an aim towards minimizing side effects.
They approve or disapprove drugs
Question:
What is polypharmacy?
Answer:
The use of 5 or more medications a day
Question:
What is Cytochrome P450 (CYP450)?
Answer:
Cytochrome P450 (CYP450) are xenobiotic-metabolizing enzymes necessary for the production of cholesterol and steroids and the detoxification of chemicals and drug metabolism.
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Question:
How many enzymes are the CYP450 system comprised of?
Answer:
The CYP450 system is comprised of 12 enzymes that are made up of three families (CYP1, CYP2, CYP3) that metabolize drugs and nine families that metabolize endogenous compounds. Many medication interactions are the result of an alteration in CYP450 metabolism
Question:
What are substrates?
Answer:
drugs that are metabolized by CYP450.
Question:
What factors affect inhibition (CYP450 Inhibitors)
Answer:
the dose and the capacity to bind to the enzyme.
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