WHITE BOOK QUESTIONS PART 2

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WHITE BOOK QUESTIONS PART 2

UPDATED ACTUAL EXAM WITH

CORRECT SOLUTIONS.

48 year old male presents to your office for angioedema. he was recently started on enalapril, an ACE inhibitor. he was seen in the emergency department during the first episode of disfiguring angioedema. the enalapril was subsequently stopped. his cardiologist would like to start him on losartan, an ARB. how long should you reccomend that the patient wait prior to starting losartan due to delayed angioedema due to ACE-I - correct answer- 6 weeks

in patients with HAE, 50% of patients will have episodes of angioedema before age 10. where is the most common site for the presentation of pain and angioedema? - correct answer- abdomen

also said extremities?

52 year old female with a history of HAE presents for a recent cluster of angioedema episodes. what recent events most likely are triggers for her symptoms. - correct answer- trauma and emotional streess

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historically the mortality rate in patients with angioedema of the oropharynx is what percent in patients with HAR? - correct answer- 30%

a major distinguishing feature of brady-kinin mediated angioedema usually is distinguished from mast cell -mediated angioedema by which factor? - correct answer- slower evoluttion, longer duration gradual worsening, slower recovery , does not respond to steroids

in patient with suspected ACE-inhibitor induced angioedema the next best step in the management of the patient would be - correct answer- stop the ACE-I irrespective of the amount of time they have on the medication

late one summer evening, you are working a night shift in the ER and a patient presents with an episode of angioedema.What lab result would most strongly suggest a diagnosis other than HAE - correct answer- normal C4

c4 is a good screening tool 100% will drop during an angioedema attack, so normal c4- think of other diagnosis

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which of the following is a correct statement about bradykinin - correct answer- increases vascular permeability by a direct effect on endothelial cells

the ultimate goal of HAR treatment is to - correct answer- minimize associated morbidity and mortality

many medication of HAE are administered intravenously. you have a patient who is very fearful of needing to have an IV placed. She would rather use subcutaneous HAE therapy.What treatment would you most likely reccomend. - correct answer- Icatibant

patient who is a professor at a local college has HAE. he has used ecallantide for the past year. he asks you how exactly it helps eliminate an angioedema episode. your best response would be - correct answer- inhibits plasma kallikrein

which of the following HAE therapies are not reccomend for women and children - correct answer- methyl-testosterone

when determining which patients require long term HAE ppx key factors to consider include - correct answer- frequency and severity of the attacks 3 / 4

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the first reported cases of angioedema were by whome - correct answer- quinke and osler

all of the following are risk factors for clinical expression of drug allergy except - correct answer- no prior reaction history

what happens when you take allopurinol on penicillin - correct answer- increase risk of rash

you are consulted for a 59 year old female who needs imaging requiring constrast media. they patient has a history of asthma, rheumatoid arthritis, and has 3 stents placed for cardiovascular disease. she has a documented penicillin allergy and her mother is allergic to radioconstrast media. the team is wondering if this patient is at risk. all of the following are risk factors for radiocontrast media - correct answer- a history of drug allergy, severe cardiovascular disease, atopic conditions, female gender

allergic patients mobilize IgE and being atopic is a major risk for penicillin anaphylaxis

what is not is rheumatological disease

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