Course: Advanced Pharmacology

Chamberlain University

NR 546 / NR546

Week 3 Antipsychotics Table

Course: Advanced Pharmacology

• / 2

Drug name Indica�on Target symptoms: state if posi�ve or nega�ve e�ect Potency (if noted. receptor occupancy if noted ) Neurotransmi�er(s) a�ected Half-life (T1/2), metabolism (CYP 450 enzyme) Notable side e�ects (associate to pathway or NT) Typical an�psycho�cs (conven�onal)

Haloperidol Target symptoms:

Manifesta�ons of psycho�c disorders Tics and vocal u�erances in Toure�e’s Syndrome Second-line treatment of severe behavior problems in children of comba�ve, explosive, hyperexcitability Second- line short-term treatment of hyperac�ve children Treatment of schizophrenic pa�ents who require prolonged parenteral an�psycho�c therapy Bipolar Disorder Behavioral disturbances in demen�as Delirium (with lorazepam) Posi�ve symptoms of psychosis, violent or aggressive behavior

Potency: High potency �rst-genera�on

Neurotransmi�er(s) a�ected:

Blocks dopamine 2 receptors, reducing posi�ve symptoms of psychosis and comba�ve, explosive, and hyperac�ve behaviors Blocks dopamine 2 receptors in the nigrostriatal pathway, improving �cs and other symptoms in Toure�e’s syndrome

Half-Life: Haldol

decanoate:

approximately 3

weeks Oral: 12-38

hours

Metabolism:

CYP1A2, CYP2D6,

CYP3A4

 Neurolep�c-induced de�cit syndrome  Akathisia  Drug-induced parkinsonism  Tardive dyskinesia, dystonia  Irreversible involuntary dyskine�c movements  Galactorrhea, amenorrhea  Dizziness, seda�on  Dry mouth  Cons�pa�on  Urinary reten�on  Blurred vision  Decreased swea�ng  Hypotension  Tachycardia  Hypertension  Weight gain

Thioridazine Target symptoms: Used for Schizophrenia in

pa�ents who fail to respond to treatment with other an�psycho�c drugs Posi�ve symptoms of psychosis Motor and autonomic hyperac�vity Violent or aggressive behavior

Potency: Low-potency �rst-genera�on

Neurotransmi�er(s) a�ected: Blocks dopamine 2

receptors, reducing posi�ve symptoms of psychosis

Half-Life: 21-24

hours

Metabolism:

CYP450 2D6

 Neurolep�c-induced de�cit syndrome  Akathisia  Priapism  Drug-induced parkinsonism  Tardive dyskinesia  Irreversible involuntary dyskine�c movements  Galactorrhea, amenorrhea  Pigmentary re�nopathy  Dizziness, seda�on Downloaded by Benjamin Luca ([email protected]) lOMoARcPSD|51648332

• / 2