Course: Advanced Pharmacology

Chamberlain University

NR 546 / NR546

Week 3 Antipsychotics Table

Course: Advanced Pharmacology

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Drug name Indica�on

Target symptoms: state if posi�ve or nega�ve

e�ect Potency (if noted. receptor occupancy if noted ) Neurotransmi�er(s) a�ected Half-life (T1/2), metabolism (CYP 450 enzyme) Notable side e�ects (associate to pathway or NT) Typical an�psycho�cs (conven�onal)

Haloperidol Target Symptoms:

Bipolar Disorder Psycho�c disorders Behavioral disturbances in demen�as Delirium w/ Lorazepam Schizophrenia Tics and vocal u�erances in Toure�es Syndrome Second line treatment of severe behavior in children of comba�ve explosive hyperexcitability

Potency:

High potency �rst-genera�on

Neurotransmi�ers:

Blocks dopamine 2 receptors, reducing posi�ve symptoms of psychosis and possibly comba�ve, explosive, and hyperac�ve behaviors Blocks dopamine 2 receptors in the nigrostriatal pathway, improving �cs and other symptoms in Toure�e’s syndrome.

Half-Life:

Decanoate is approx.

• weeks

Oral: 12-38 hours

Metabolism:

CYP1A2

CYP2D6

CYP3A4

Notable Side E�ects:

Neurolep�c-induced de�cit syndrome Akathisia Drug-induced Parkinsonism Tardive dyskinesia, Tardive dystonia Risk of poten�ally irreversible involuntary dyskine�c movements may increase with cumula�ve dose and treatment dura�on Galactorrhea, Amenorrhea Dizziness Seda�on Dry mouth, cons�pa�on, urinary reten�on, blurred vision Decreased swea�ng Hypotension Tachycardia Hypertension Weight gain

Thioridazine Target Symptoms:

Schizophrenia

Potency:

Low-potency �rst-genera�on

Neurotransmi�ers:

Blocks dopamine 2 receptors, reducing posi�ve symptoms of psychosis

Half-Life:

21-24 Hours

Metabolism:

CYP450 2D6

Notable Side E�ects:

Neurolep�c-induced de�cit syndrome Akathisia Priapism Drug- induced parkinsonism Tardive dyskinesia Risk of poten�ally irreversible involuntary dyskine�c movements may increase with cumula�ve dose Downloaded by Benjamin Luca ([email protected]) lOMoARcPSD|51648332

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