Course: Advanced Pharmacology

Chamberlain University

NR 546 / NR546

Week 4 Anxiolytic Table

Course: Advanced Pharmacology

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Anxioly�c Medica�ons Drug Name/ Medica�on class Indica�on list diagnosis and targeted symptoms Associated Neurotransmi�ers Half-life (T1/2) Metabolism (CYP 450 enzyme) Notable side e�ects Gabapen�nPar�al seizures Postherpe�c neuralgia Restless leg syndrome Neuropathic pain/ chronic pain Anxiety Bipolar disorder Binds to the alpha

• delta subunit of

voltage-sensi�ve calcium channels Half-Life 5-7 hrs.Metabolism Does not metabolize but excreted intact renally Seda�on, dizziness Ataxia, fa�gue, nystagmus, tremor Peripheral edema Blurred vision Vomi�ng, dyspepsia, diarrhea, dry mouth, cons�pa�on, weight gain

Addi�onal e�ects in children under 12:

hos�lity, emo�onal lability, hyperkinesia, thought disorder, weight gain Pregabalin Diabe�c peripheral neuropathy Postherpe�c neuralgia Fibromyalgia Neuropathic pain associated with spinal cord injury Par�al onset seizures in adults and pediatric pa�ents Peripheral neuropathic pain

GAD

Panic disorder Social anxiety disorder Binds to the alpha

• delta subunit of

voltage-sensi�ve calcium channels Half-Life 5-7 hours Metabolism Pregabalin is not metabolized but excreted intact renally Seda�on, dizziness Ataxia, fa�gue, tremor, dysarthria, paresthesia, memory impairment, coordina�on abnormal, impaired a�en�on, confusion, euphoric mood, irritability Vomi�ng, dry mouth, cons�pa�on, weight gain, increased appe�te, �atulence Blurred vision, diplopia Peripheral Edema Libido decreased, erec�le dysfunc�on Buspirone Major depressive disorder Seasonal a�ec�ve disorder Nico�ne addic�on Bipolar depression A�en�on de�cit hyperac�vity disorder

(ADHD)

Sexual Dysfunc�on Boost neurotransmi�er norepinephrine/n oradrenaline and dopamine Blocks norepinephrine reuptake pump, presumably increasing Half life

Parent: 10-14 Hrs.

Metabolite: 20-

27Hrs.Metabolism

CYP450 2D6

Dry mouth, cons�pa�on, nausea, weight loss, anorexia, myalgia Insomnia, dizziness, headache, agita�on, anxiety, tremor, abdominal pain, �nnitus Swea�ng Rash Hypertension Downloaded by Benjamin Luca ([email protected]) lOMoARcPSD|51648332

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