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Midterm Exam: NR 567 / NR567
(Latest Update 2025 / 2026) Advanced Pharmacology for the AGACNP | Questions & Answers | Grade A | 100% Correct – Chamberlain
Question:
What is the primary action of Erythromycin?
Answer:
Erythromycin is usually bacteriostatic but can be bactericidal against highly susceptible organisms or at high concentrations.
Question:
What are the indications for Erythromycin?
Answer:
Whooping Cough, Diphtheria, Chlamydia, Pneumonia.
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Question:
What are common side effects of Erythromycin?
Answer:
GI effects (epigastric pain, N/V/D), superinfection, cardiac effects (QT prolongation and sudden cardiac death), thrombophlebitis, transient hearing loss, hypertrophic pyloric stenosis.
Question:
What precautions should be taken when prescribing Erythromycin?
Answer:
Avoid in clients with congenital QT prolongation and those taking class IA or III antidysrhythmic agents or CYP3A4 inhibitors.
Question:
What labs should be monitored for patients on Erythromycin?
Answer:
Liver function tests (LFTs), serum drug levels, coagulation studies in clients taking warfarin.
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Question:
What is Epoetin Alfa used for?
Answer:
Epoetin Alfa is used to treat anemia in chronic kidney disease (CKD) when hemoglobin is <9-10 g/dL.
Question:
What is the mechanism of action of Epoetin Alfa?
Answer:
It augments endogenous erythropoietin hormone by stimulating iron uptake and heme biosynthesis in erythroid precursors.
Question:
What is the dosing regimen for Epoetin Alfa in CKD clients on dialysis?
Answer:
Starting doses are 50-100 units/kg SC or IV, three times weekly, with a maximum of 10,000 units three times weekly.
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Question:
How should Epoetin Alfa doses be adjusted based on hemoglobin levels?
Answer:
Increase by 25% if Hgb does not increase by >1g/dL at four weeks; reduce by 25% if Hgb increases by >1g/dL in any 2-week period.
Question:
What are the side effects of Epoetin Alfa?
Answer:
Hypertension, increased risk of cardiovascular events, rare pure red-cell aplasia.
Question:
What are the contraindications for Epoetin Alfa?
Answer:
Uncontrolled hypertension, hemoglobin > 11, hypersensitivity.
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