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NR565 / NR 565 Advanced Pharmacology Fundamentals Midterm Exam Study Guide 100% Guarantee Pass
- During what trimester is a pregnant woman most at risk for adverse drug
reactions with potential long term consequences?Answer 1st trimester (fetus most at risk d/t rapid growth)
- What is BEERS criteria?
Answer Recommendations of medications inappropriate for elderly (65 and older), prescriber ultimately decides
- What is the CYP450 (cytochrome P450)
Answer liver enzyme system where medica- tions are metabolized, can either be inducers or inhibitors and create drug-drug interactions
- CYP450 inducers Joshua 1 / 8
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Answer Speed up metabolism of drugs (drug is cleared faster), drug has lesser effect (decrease blood levels of drug), elevate CYP450 enzymes
- CYP450 inducers pneumonic
Answer "Bullshit Crap GPS INDUCES rage"
- CYP450 inducer drug names
Answer Barbituates, St John wort, Carbamazepine, rifampin, alcohol, phenytoin, griseofulvin, phenobarbital, sulfonylureas
- CYP450 inhibitors
Answer inhibit metabolism, increase blood levels of medications
- CYP450 pneumonic
Answer "VISA credit card debt INHIBITS spending on designers like CK to look GQ"
- CYP450 inhibitors drug names
Answer Valproate, isoniazid, sulfonamides, amiodarone, chloramphenicol, Joshua 2 / 8
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ketoconazole, grapefruit juice, quinidine
- Physiological changes during pregnancy that impact pharmacodynamics
and pharmacokinetic properties of drugs?Answer increase glomerular filtration rate leads to increase durg excretion increase hepatic metabolism decrease tone and motility of bowel increase drug absorption
- Examples of medications that can be teratogenic
Answer Antiepileptic drugs, an- timicrobials such as tetracyclines and fluoroquinolones, vitamin A in large doses, some anticoagulants, and hormonal medications such as diethylstilbestrol (DES).
- How is absorption of intramuscular medications different in neonates?
Answer - slow and erratic due to low blood flow in muscles first few days of life
- Why is absorption of medication in the stomach increased in infancy?
Answer de- layed gastric emptying Joshua 3 / 8
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- Some medications that should be avoided in the pediatric patient?
Answer glu- cocorticoids, discoloration of developing teeth with tetracyclines, and kernicterus with sulfonamides, levofloxacin (antibiotics) aspirin (Severe intoxication from acute overdose)
- what should be included in medication administration patient education?-
Answer dosage size and timing route and technique of administration duration of treatment drug storage nature and time course of desired responses nature and time course of adverse responses finish taking antibiotic
- What are some things that put the elderly patient at higher risk for adverse
drug reactions?Answer reduced renal function polypharmacy (the use of five or more medications daily) greater severity of illness Joshua 4 / 8
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