Midterml Exam:l NRl 566l NR566l Latestl

Midterml Exam:l NRl 566/l NR566l (Latestl

2026/l 2027l Update)l Advancedl Pharmacologyl forl Carel ofl thel Familyl Guide|l Q/Al |l Gradel A|l 100%l Correctl (Verifiedl Answers)l -Chamberlain

Q:l Acyclovirl MOA

Answer:

Inhibitsl virall DNAl synthesisl byl inhibitingl virall DNAl polymerasel andl incorporatingl intol growingl strandsl ofl virall DNA

Q:l Acyclovirl indications

Answer:

herpesl (genital/coldl sores),l herpesl zosterl (shingles),l varicellal (chickenl pox)

Q:l Acyclovirl Routesl ofl Administration

Answer:

topical,l oral,l IV -orall bioavailabilityl isl lowl (15-30%) -nol significantl absorptionl w/l topicall -half-lifel isl 2.5hrl (PROLONGEDl W/l RENALl PTSl REDUCEl DOSE)

Q:l Acyclovirl routel ofl administrationl consideration

Answer:

-oral:l h/a,l n/v/d,l vertigo,l safel w/l preg 1 / 4

-topical:l burning,l stingingl

-IV:l phlebitis,l inflammation,l reversiblel nephrotoxicity,l neurotoxicityl (obese/CKD)

Q:l Oseltamivirl (Tamiflu)l MOA

Answer:

-neuraminidasel inhibitor

Q:l Neuraminidase

Answer:

virall enzymel neededl forl replication

Q:l Oseltamivirl (Tamiflu)l administration

Answer:

POl (orall suspension/capsules)

Q:l Oseltamivirl (Tamiflu)l indications

Answer:

-Flul Al &l B -givenl w/inl 48hrl exposurel forl 10l days

Q:l Palivizumabl indications

Answer:

RSVl prophylaxisl vial IM,l monthlyl injection

Q:l purposel ofl annuall flul vaccine

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Answer:

-importantl forl peoplel w/l highl riskl forl flul complicationsa

Q:l flul vaccinel contraindications

Answer:

-anaphylacticl rxnl tol flul vaccine/vaccinel componentl -hxl ofl GBSl -inactivatedl forml forl thosel thatl arel immunol compromised

Q:l HIVl treatment

Answer:

-Antiretrovirall therapyl (ART):l 3-4l drugs

-decreasesl plasmal HIVl tol levelsl undetectablel l lifel long

Q:l Antiretrovirall drugl classesl (8)

Answer:

1.l Nucleosidel reversel transcriptasel inhibitorsl (NRTIs)

2.l Non-nucleosidel reversel transcriptasel inhibitorsl (NNRTIs)

3.l Proteasel inhibitorsl (PIs)

4.l Integrasel strandl transferl inhibitorsl (INSTIs)

5.l Fusionl proteinl inhibitors

6.l CCR5l antagonists

7.l Attachmentl inhibitors

8.l Postattachmentl inhibitors

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Q:l NRTIsl MOA

Answer:

-firstl drugl againstl HIV -examplel abacavir -inhibitl HIVl replicationl byl suppressingl synl ofl virall DNA

Q:l NRTIsl Adversel Effectsl (4)

Answer:

1.l lacticl acidosisl 2.l hepaticl steatosis 3.l pancreatitisl 4.l myopathies

Q:l Proteasel inhibitorsl MOA

Answer:

-preventsl HIVl maturationl byl blockingl HIVl enzymel protease

Q:l Proteasel inhibitorsl adversel effectsl (5)

Answer:

1.l hyperglycemial &l developmentl ofl DMl 2.l lipodystrophyl 3.l elevatedl transaminasesl 4.l decreasedl cardiacl conductionl 5.l bleedingl inl hemophilia

Q:l Proteasel inhibitorsl prescribingl considerations

Answer:

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