PCEUT 531 ACTUAL EXAM 1 QUESTIONS WITH

PCEUT 531 (ACTUAL / ) EXAM 1 QUESTIONS WITH

VERIFIED CORRECT ANSWERS

Codeine elixir - ---Answers----it is not self preserving, sodium benzoate is an anti microbial preservative NOT citric acid, propylene glycol is NOT a viscosity agent and saccharin sodium is not an antioxidant

Non-sterile formulation for power for suspension - --- Answers----for alcoholic aqueous liquids, the final volume should be read by measuring at eye level from the bottom of the meniscus, since the final volume is greater than 1.5mL a syringe may be used to draw it up, but the precisions of the final volume is NOT limited by interval size of the graduations on the cylinder

extemporaneous communition and mixing powders - --- Answers----finer end product can be achieved using a mortar and pestle, only pharm or tech can perform this, this is non- sterile compounding

surfactants - ---Answers----amphiphiles

cohesive force> adhesive force - ---Answers----tends to be no mixing

Surfactants spontaneously concentrating at interface results in what - ---Answers----decrease in interfacial tension 1 / 3

Micelles are formed below CMS of surfactants - ---Answers--

--FALSE

Nonionic surfactants can be mixed with cationic or anionic surfactants without affecting their properties - ---Answers--- -TRUE

Higher HLB - ---Answers----more hydrophilic, NOT hydrophobic

Cationic surfactants - ---Answers----are strong antimicrobial agents but poor surfactants

anionic surfactants - ---Answers----irritate the GI tract and are not stable at pH<10

HLB value - ---Answers----determines how a surfactant may be used in pharmaceutical formulations

W/O emulsion droplets - ---Answers----will sediment not cream

O/W emulsions - ---Answers----can be made with hydrophilic colloids and can be used to administer oil soluble drugs. They are not made with hydrophobic emulsifying agents

• / 3

If a surfactant is used to make an O/W emulsions for oral administration - ---Answers----a nonionic surfactant will most likely be used because they are most widely used

Fine zinc powder can be used as an emulsifying agent because it can reduce interfacial tension - ---Answers----FALSE it cannot reduce interfacial tension at all

Cracking of emulsions - ---Answers----irreversible process due to loss of function of emulsifying agents

Type of emulsify can be changed by addition of electrolytes or water - ---Answers----TRUE

The velocity of sedimentation of droplets in an emulsion can be reduced how? - ---Answers----by adding a viscosity agent NOT a wetting agent

Cracking - ---Answers----aggregation and coalescence of droplets to form separate phases

creaming - ---Answers----instability of emulsions

Suspensions are products resulting from what - ---Answers- ---incorporating insoluble drugs and additives into a liquid medium

• / 3