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Nursing Pharmacology ScienceMedicine MLLangevin Save Nursing Pharmacology (Drugs) 150 terms Sarah_ShanerPreview Pharmacology Exam 1 - Multiple Ch...100 terms dsg2000Preview Pharmacology NCLEX Questions 49 terms notnursingPreview Pharma Teacher will Learn1 / 7Study using Learn types of drug effects that are less serious than adverse effects, are predictable and may occur even at therapeutic doses Absorption the process by which drug molecules move from their site of administration to the blood Choose an answer additive effect synergistic effect side effect toxic effect Don't know?

Affinity the ability of some tissues to attract, accumulate and store drugs in high concentrations relative to other tissues blood-brain barrier Blood vessels (capillaries) that selectively let certain substances enter the brain tissue and keep other substances out diffusion process by which molecules tend to move from an area where they are more concentrated to an area where they are less concentrated distribution the transport of drugs throughout the body after they are absorbed drug-protein complexes formed when a drugh that binds reversibly to a plasma protein, particularly albumin, that makes the drug unavailable for distribution to its site of action enterohepatic recirculation recycling of drugs and other substances by the circulation of bile through the intestine and liver enzyme induction process by whick a drug increases the activity of the hepatic microsomal enzymes excretion the process of removing substances from the body first-pass effect mechanism whereby drugs are absorbed enter into the hepatic portal circulation and are inactivated by the liver before they reach the general circulation fetal-placental barrier special anatomic barrier that inhibits many chemicals and drugs from entering the fetus hepatic microsomal enzyme system as it relates to phamacotherapy, liver enzymes that metabolize drugs as well as nutrients and other endogenous substances, sometimes called the P-450 System

isozymes multiple similar forms of an enzyme that perform slightly different metabolic functions loading dose relatively large dose of a drug given at the beginning of treatment to rapidly obtain a therapeutic response maintenance doses amount of drug that keeps the plasma drug concentration in the therapeutic range metabolism the process used by the body to chemically change a drug molecule, also called biotransformation minimum effective concentration amount of drug required to produce a therapeutic effect pharmacokinetics study of drug movement throughout the body plasma half-life the length of time required for the plasma concentration of a drug to decrease by one half after administration prodrugs drugs that become more active after they are metabolized substrate drug that is metabolized by a CYP enzyme therapeutic drug monitoring practice of monitoring plasma levels of drughs that have low safety profiles and using the data to predict drugh action or toxicity therapeutic range dosage that produces the desired effects of a drug toxic concentration level of drug that results in serious adverse effects

agonist drug that activates a receptor and produces the same type of response as the endogenous substance antagonist agent that blocks the response of another drug dose-response relationship the way a patient responds to varying doses of a drug efficacy the maximal response that can be produced from a particular drug frequency distrubtion curve a graphic representation of the actual number of patients responding to a particular drug action at different doses idiosyncratic response unpredictable and unexplained drug reaction intrinsic activity the ability of a drug to bind to a receptor and produce a strong action margin of safety (MOS) the amount of drug that is lethal to 1% of anmals divided by the amount of drug that produces a therapeutic effect in 99% of the animals median effective dose (ED50) the dose of a drug required to produce a specific therapeutic response in 50% of a group of patients median lethal dose (LD50) the dose of a drug that will kill 50% if a group of animals median toxicity dose (TD50) the dose that will produce a given toxicity in 50% of a group of patients partial agonist medication that produces weaker or less efficacious response than an agonist